منابع مشابه
Biological aromatization of steroids.
The conversion of androgenic steroids to the phenolic estrogens by mammalian tissue has been well documented. The reaction has been reported in relatively low yield, in vitro with ovarian and placental slices (l-3), and in viva after the administration of androgens to various species including man (4, 5). The present report describes the conversion of androgens to estrogens in high yield by a s...
متن کاملMicrobial aromatization of steroids into equilin.
This report describes the bioconversion of 19-hydroxy-androsta-4, 7-diene-3, 17-dione into equilin with Nocardia rubra. Through mutation and improvement of medium and of conditions, the bioconversion could be improved to yield 40% equilin for a substrate concentration of 1 g/liter. Aromatization of several other 19-hydroxy and 19-nor substrates of the androstene series is reported, and the infl...
متن کاملEnzymatic aromatization of steroids. I. Effects of oxygen and carbon monoxide on the intermediate steps of estrogen biosynthesis.
At Case Western Reserve University in Cleveland, the known intermediate steps in the aromatization, catalyxed by human placental microsomes, of 4-androstene-3, 17-dione to estrone were evaluated. Oxygen and carbon monoxide atmospheres were used to expose the properties of the participating oxidases. The results were judged to be evidence for the existence of 3 mixed function oxidases active i...
متن کاملPrinciples of the enzymatic measurement of steroids.
Information on steroid concentrations in tissues is important for an understanding of the metabolism of these substances and also for diagnostic purposes in certain clinical conditions. Existing procedures for determining steroids, either singly or in mixtures, are based upon calorimetric methods or tedious bioassays. The merits and limitations of these procedures have been critically appraised...
متن کاملAromatization of cyclohexanecarboxylic acid.
An enzyme which catalyzes the aromatization of cyclohexanecarboxyl coenzyme A has been isolated from whole liver as well as from liver mitochondria. Incubation of the soluble, partially purified enzyme with cyclohexanecarboxyl-CoA produces cyclohexene-l-carboxyl-CoA, benzoyl-CoA, and a polar compound which has not. been further characterized. All three isomers of cyclohexenecarboxyl-CoA are con...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1971
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)62535-9